Innate Immune Activation with Multifunctional Nanoparticles for Cancer Immunotherapy
Xiaomin Jiang, Wenbin Lin*Angew. Chem. Int. Ed. 2025, e202423280. Cationic Metal-Organic Layer Delivers siRNAs to Overcome Radioresistance and Potentiate Cancer Radiotherapy
Xin Ma#, Xiaomin Jiang#, Zitong Wang#, Yingjie Fan, Jinhong Li, Cathleen Chow, Chaoyu Wang, Chenghua Deng, Wenbin Lin*Angew. Chem. Int. Ed. 2024, e202419409 Bifunctional Metal-Organic Framework Synergistically Enhances
Radiotherapy and Activates STING for Potent Cancer Radio-
Immunotherapy
Chaoyu Wang#, Jinhong Li# , Xiaomin Jiang#, Xin Ma, Wenyao Zhen, Langston Tillman, Ralph R. Weichselbaum*, Wenbin Lin*Angew. Chem. Int. Ed. 2024, e202417027 STING activation disrupts tumor vasculature to overcome the EPR limitation and increase drug deposition
Xiaomin Jiang, Taokun Luo, Kaiting Yang, Morten J Lee, Jing Liu, Langston Tillman, Wenyao Zhen, Ralph R Weichselbaum, Wenbin Lin* (highlighted by UChicago news & UChicago BSD news!)Sci. Adv. 10 (29), eado0082 Nanoscale Mixed-Ligand Metal–Organic Framework for X-ray Stimulated Cancer Therapy
Wenyao Zhen, Ziwan Xu, Yibin Mao, Caroline McCleary, Xiaomin Jiang, Ralph R Weichselbaum, Wenbin Lin*J. Am. Chem. Soc. 2024, 146, 48, 33149–33158 Nitric Oxide-Releasing Nanoscale Metal-Organic LayerOvercomes Hypoxia and Reactive Oxygen Species DiffusionBarriers to Enhance Cancer Radiotherapy
Yuxuan Xiong, Jinhong Li, Xiaomin Jiang, Wenyao Zhen, Xin Ma, and Wenbin Lin*Adv. Sci. 2024, 2413518. Nanoscale Metal‐Organic Layer Reprograms Cellular Metabolism to Enhance Photodynamic Therapy and Antitumor Immunity
Gan Lin, Langston Tillman, Taokun Luo, Xiaomin Jiang, Yingjie Fan, Gang Liu, Wenbin Lin*Angew. Chem. Int. Ed. 2024, e202410241. STING agonist-conjugated metal-organic framework induces artificial leukocytoid structures and immune hotspots for systemic antitumor responses
Taokun Luo#, Xiaomin Jiang#, Yingjie Fan, Eric Yuan, Jinhong Li, Langston Tillman, Wenbin Lin*Natl. Sci. Rev. 2024, 10, nwae167. Phosphate Coordination to Metal-Organic Layer Secondary Building Units Prolongs Drug Retention for Synergistic Chemoradiotherapy
Taokun Luo#, Xiaomin Jiang#, Jinhong Li#, Geoffrey T Nash, Eric Yuan, Luciana Albano, Langston Tillman, Wenbin Lin*Angew. Chem. Int. Ed. 2024, 63, e202319981. Immunogenic Bifunctional Nanoparticle Suppresses Programmed Cell Death-Ligand 1 in Cancer and Dendritic Cells to Enhance Adaptive Immunity and Chemo-Immunotherapy
Jing Liu#, Xiaomin Jiang#, Youyou Li, Kaiting Yang, Ralph R Weichselbaum*, Wenbin Lin*ACS Nano 2024, 18, 6, 5152–5166. Nanoscale covalent organic framework with staggered stacking of phthalocyanines for mitochondria-targeted photodynamic therapy
Jing Liu, Dong Won Kang, Yingjie Fan, Geoffrey T Nash, Xiaomin Jiang, Ralph R Weichselbaum, Wenbin Lin*J. Am. Chem. Soc. 2024, 146, 1, 849–857. Mechanoregulatory Cholesterol Oxidase‐Functionalized Nanoscale Metal–Organic Framework Stimulates Pyroptosis and Reinvigorates T Cells
Wenyao Zhen, Taokun Luo, Zitong Wang, Xiaomin Jiang, Eric Yuan, Ralph R Weichselbaum, Wenbin Lin*Small 2023, 2305440. Nanoscale Coordination Polymer Synergizes Photodynamic Therapy and Toll-Like Receptor Activation for Enhanced Antigen Presentation and Antitumor Immunity
Xiaomin Jiang, Jing Liu, Morten J. Lee, Cheng Peng, Taokun Luo, Langston Tillman, Ralph R. Weichselbaum, Wenbin Lin*Biomaterials 2023, 302, 122334. Co-delivery of Three Synergistic Chemotherapeutics in A Core-Shell Nanoscale Coordination Polymer for the Treatment of Pancreatic Cancer
Xiaomin Jiang, Morten J. Lee, Taokun Luo, Langston Tillman, Wenbin Lin*Biomaterials 2023, 301, 122235. Nanoscale Metal–Organic Framework with an X-ray Triggerable Prodrug for Synergistic Radiotherapy and Chemotherapy
Ziwan Xu, Wenyao Zhen, Caroline McCleary, Taokun Luo, Xiaomin Jiang, Cheng Peng, Ralph R Weichselbaum, Wenbin Lin*J. Am. Chem. Soc. 2023, 145, 18698-18704. Metal‐Organic Layer Delivers 5‐Aminolevulinic Acid and Porphyrin for Dual‐Organelle‐Targeted Photodynamic Therapy
Taokun Luo, Yingjie Fan, Jianming Mao, Xiaomin Jiang, Luciana Albano, Eric Yuan, Tomas Germanas, Wenbin Lin*Angew. Chem. Int. Ed. 2023, 62, e202301910. Pharmacological ascorbate potentiates combination nanomedicines and reduces cancer cell stemness to prevent post-surgery recurrence and systemic metastasis
Xiaomin Jiang, Jianqiao Liu, Jianming Mao, Wenbo Han, Yingjie Fan, Taokun Luo, Junjie Xia, Morten J Lee, Wenbin Lin*Biomaterials 2023, 295, 122037. A Three-in-One Nanoscale Coordination Polymer for Potent Chemo-Immunotherapy
Jing Liu#, Xiaomin Jiang#, Xuanyu Feng, Morten J Lee, Youyou Li, Jianming Mao, Ralph R Weichselbaum, Wenbin Lin*Small Method. 2023, 2201437. Two-stage SN38 release from a core–shell nanoparticle enhances tumor deposition and antitumor efficacy for synergistic combination with immune checkpoint blockade
Xiaomin Jiang, Morten Lee, Junjie Xia, Taokun Luo, Jianqiao Liu, Megan Rodriguez, Wenbin Lin*ACS Nano 2022, 16, 21417–21430 Zinc cyclic di-AMP nanoparticles target and suppress tumours via endothelial STING activation and tumour-associated macrophage reinvigoration
Kaiting Yang#, Wenbo Han#, Xiaomin Jiang#, Andras Piffko, Jason Bugno, Chuanhui Han, Sirui Li, Hua Liang, Ziwan Xu, Wenxin Zheng, Liangliang Wang, Jiaai Wang, Xiaona Huang, Jenny PY Ting, Yang-Xin Fu, Wenbin Lin*, Ralph R Weichselbaum*Nat. Nanotech. 2022, 17, 1322-1331. TLR3 agonist nanoscale coordination polymer synergizes with immune checkpoint blockade for immunotherapy of cancer
Yingying Li#, Xiaomin Jiang#, Taokun Luo, Junjie Xia, Morten J Lee, Ralph R Weichselbaum*, Wenbin Lin*Biomaterials 2022, 290, 121831. A 2D Nanoradiosensitizer Enhances Radiotherapy and Delivers STING Agonists to Potentiate Cancer Immunotherapy
Taokun Luo, Geoffrey T Nash, Xiaomin Jiang, Xuanyu Feng, Jianming Mao, Jianqiao Liu, Aditya Juloori, Alexander T Pearson, Wenbin Lin*Adv. Mater. 2022, 34, 2110588. Tumor‐Activatable Nanoparticles Target Low‐Density Lipoprotein Receptor to Enhance Drug Delivery and Antitumor Efficacy
Xiaomin Jiang, Wenbo Han, Jianqiao Liu, Jianming Mao, Morten J Lee, Megan Rodriguez, Youyou Li, Taokun Luo, Ziwan Xu, Kaiting Yang, Marc Bissonnette, Ralph R Weichselbaum, Wenbin Lin*Adv. Sci. 2022, 2201614. Nanoscale coordination polymers for combined chemotherapy and photodynamic therapy of metastatic cancer
Youyou Li, Wenbo Han, Chunbai He, Xiaomin Jiang, Yingjie Fan, Wenbin Lin*Bioconjugate Chem. 2021, 32, 2318-2326. Nanoscale metal–organic framework confines zinc-phthalocyanine photosensitizers for enhanced photodynamic therapy
Taokun Luo, Geoffrey T Nash, Ziwan Xu, Xiaomin Jiang, Jianqiao Liu, Wenbin Lin*J. Am. Chem. Soc. 2021, 143, 34, 13519–13524. Supramolecular metal-based nanoparticles for drug delivery and cancer therapy
Xiaomin Jiang, Chunbai He, Wenbin Lin*Curr. Opin. in Chem. Biol., 2021, 61, 143-153. Point-source burst of coordination polymer nanoparticles for tri-modality cancer therapy
Xiang Ling#, Wenbo Han#, Xiaomin Jiang#, Xing Chen, Megan Rodriguez, Pingping Zhu, Tong Wu, Wenbin Lin*Biomaterials 2021, 270, 120690. Sequential treatment of bioresponsive nanoparticles elicits antiangiogenesis and apoptosis and synergizes with a CD40 agonist for antitumor immunity
Xiang Ling, Xiaomin Jiang, Youyou Li, Wenbo Han, Megan Rodriguez, Ziwan Xu, Wenbin Lin*ACS Nano 2021, 15, 765-780. Nanoscale metal–organic frameworks stabilize bacteriochlorins for type I and type II photodynamic therapy
Taokun Luo, Kaiyuan Ni, August Culbert, Guangxu Lan, Zhe Li, Xiaomin Jiang, Michael Kaufmann, Wenbin Lin*J. Am. Chem. Soc. 2021, 143, 34, 13519–13524. The cytochrome c–cyclo [6] aramide complex as a supramolecular catalyst in methanol
Wang Pan, Lijun Mao, Mingsong Shi, Yonghong Fu, Xiaomin Jiang, Wen Feng, Youzhou He, Dingguo Xu, Lihua Yuan*New J. Chem., 2018, 42, 3857-3866.