Innate Immune Activation with Multifunctional Nanoparticles for Cancer Immunotherapy 

Xiaomin Jiang, Wenbin Lin*
Angew. Chem. Int. Ed. 2025, e202423280.

 Cationic Metal-Organic Layer Delivers siRNAs to Overcome Radioresistance and Potentiate Cancer Radiotherapy 

Xin Ma#, Xiaomin Jiang#, Zitong Wang#, Yingjie Fan, Jinhong Li, Cathleen Chow, Chaoyu Wang, Chenghua Deng, Wenbin Lin*
Angew. Chem. Int. Ed. 2024, e202419409

 Bifunctional Metal-Organic Framework Synergistically Enhances Radiotherapy and Activates STING for Potent Cancer Radio- Immunotherapy 

Chaoyu Wang#, Jinhong Li# , Xiaomin Jiang#, Xin Ma, Wenyao Zhen, Langston Tillman, Ralph R. Weichselbaum*, Wenbin Lin*
Angew. Chem. Int. Ed. 2024, e202417027

 STING activation disrupts tumor vasculature to overcome the EPR limitation and increase drug deposition 

Xiaomin Jiang, Taokun Luo, Kaiting Yang, Morten J Lee, Jing Liu, Langston Tillman, Wenyao Zhen, Ralph R Weichselbaum, Wenbin Lin* (highlighted by UChicago news & UChicago BSD news!)
Sci. Adv. 10 (29), eado0082

 Nanoscale Mixed-Ligand Metal–Organic Framework for X-ray Stimulated Cancer Therapy 

Wenyao Zhen, Ziwan Xu, Yibin Mao, Caroline McCleary, Xiaomin Jiang, Ralph R Weichselbaum, Wenbin Lin*
J. Am. Chem. Soc. 2024, 146, 48, 33149–33158

 Nitric Oxide-Releasing Nanoscale Metal-Organic LayerOvercomes Hypoxia and Reactive Oxygen Species DiffusionBarriers to Enhance Cancer Radiotherapy 

Yuxuan Xiong, Jinhong Li, Xiaomin Jiang, Wenyao Zhen, Xin Ma, and Wenbin Lin*
Adv. Sci. 2024, 2413518.

 Nanoscale Metal‐Organic Layer Reprograms Cellular Metabolism to Enhance Photodynamic Therapy and Antitumor Immunity 

Gan Lin, Langston Tillman, Taokun Luo, Xiaomin Jiang, Yingjie Fan, Gang Liu, Wenbin Lin*
Angew. Chem. Int. Ed. 2024, e202410241.

 STING agonist-conjugated metal-organic framework induces artificial leukocytoid structures and immune hotspots for systemic antitumor responses 

Taokun Luo#, Xiaomin Jiang#, Yingjie Fan, Eric Yuan, Jinhong Li, Langston Tillman, Wenbin Lin*
Natl. Sci. Rev. 2024, 10, nwae167.

 Phosphate Coordination to Metal-Organic Layer Secondary Building Units Prolongs Drug Retention for Synergistic Chemoradiotherapy 

Taokun Luo#, Xiaomin Jiang#, Jinhong Li#, Geoffrey T Nash, Eric Yuan, Luciana Albano, Langston Tillman, Wenbin Lin*
Angew. Chem. Int. Ed. 2024, 63, e202319981.

 Immunogenic Bifunctional Nanoparticle Suppresses Programmed Cell Death-Ligand 1 in Cancer and Dendritic Cells to Enhance Adaptive Immunity and Chemo-Immunotherapy 

Jing Liu#, Xiaomin Jiang#, Youyou Li, Kaiting Yang, Ralph R Weichselbaum*, Wenbin Lin*
ACS Nano 2024, 18, 6, 5152–5166.

 Nanoscale covalent organic framework with staggered stacking of phthalocyanines for mitochondria-targeted photodynamic therapy 

Jing Liu, Dong Won Kang, Yingjie Fan, Geoffrey T Nash, Xiaomin Jiang, Ralph R Weichselbaum, Wenbin Lin*
J. Am. Chem. Soc. 2024, 146, 1, 849–857.

 Mechanoregulatory Cholesterol Oxidase‐Functionalized Nanoscale Metal–Organic Framework Stimulates Pyroptosis and Reinvigorates T Cells 

Wenyao Zhen, Taokun Luo, Zitong Wang, Xiaomin Jiang, Eric Yuan, Ralph R Weichselbaum, Wenbin Lin*
Small 2023, 2305440.

 Nanoscale Coordination Polymer Synergizes Photodynamic Therapy and Toll-Like Receptor Activation for Enhanced Antigen Presentation and Antitumor Immunity 

Xiaomin Jiang, Jing Liu, Morten J. Lee, Cheng Peng, Taokun Luo, Langston Tillman, Ralph R. Weichselbaum, Wenbin Lin*
Biomaterials 2023, 302, 122334.

 Co-delivery of Three Synergistic Chemotherapeutics in A Core-Shell Nanoscale Coordination Polymer for the Treatment of Pancreatic Cancer 

Xiaomin Jiang, Morten J. Lee, Taokun Luo, Langston Tillman, Wenbin Lin*
Biomaterials 2023, 301, 122235.

 Nanoscale Metal–Organic Framework with an X-ray Triggerable Prodrug for Synergistic Radiotherapy and Chemotherapy 

Ziwan Xu, Wenyao Zhen, Caroline McCleary, Taokun Luo, Xiaomin Jiang, Cheng Peng, Ralph R Weichselbaum, Wenbin Lin*
J. Am. Chem. Soc. 2023, 145, 18698-18704.

 Metal‐Organic Layer Delivers 5‐Aminolevulinic Acid and Porphyrin for Dual‐Organelle‐Targeted Photodynamic Therapy 

Taokun Luo, Yingjie Fan, Jianming Mao, Xiaomin Jiang, Luciana Albano, Eric Yuan, Tomas Germanas, Wenbin Lin*
Angew. Chem. Int. Ed. 2023, 62, e202301910.

 Pharmacological ascorbate potentiates combination nanomedicines and reduces cancer cell stemness to prevent post-surgery recurrence and systemic metastasis 

Xiaomin Jiang, Jianqiao Liu, Jianming Mao, Wenbo Han, Yingjie Fan, Taokun Luo, Junjie Xia, Morten J Lee, Wenbin Lin*
Biomaterials 2023, 295, 122037.

 A Three-in-One Nanoscale Coordination Polymer for Potent Chemo-Immunotherapy 

Jing Liu#, Xiaomin Jiang#, Xuanyu Feng, Morten J Lee, Youyou Li, Jianming Mao, Ralph R Weichselbaum, Wenbin Lin*
Small Method. 2023, 2201437.

 Two-stage SN38 release from a core–shell nanoparticle enhances tumor deposition and antitumor efficacy for synergistic combination with immune checkpoint blockade 

Xiaomin Jiang, Morten Lee, Junjie Xia, Taokun Luo, Jianqiao Liu, Megan Rodriguez, Wenbin Lin*
ACS Nano 2022, 16, 21417–21430

 Zinc cyclic di-AMP nanoparticles target and suppress tumours via endothelial STING activation and tumour-associated macrophage reinvigoration 

Kaiting Yang#, Wenbo Han#, Xiaomin Jiang#, Andras Piffko, Jason Bugno, Chuanhui Han, Sirui Li, Hua Liang, Ziwan Xu, Wenxin Zheng, Liangliang Wang, Jiaai Wang, Xiaona Huang, Jenny PY Ting, Yang-Xin Fu, Wenbin Lin*, Ralph R Weichselbaum*
Nat. Nanotech. 2022, 17, 1322-1331.

 TLR3 agonist nanoscale coordination polymer synergizes with immune checkpoint blockade for immunotherapy of cancer 

Yingying Li#, Xiaomin Jiang#, Taokun Luo, Junjie Xia, Morten J Lee, Ralph R Weichselbaum*, Wenbin Lin*
Biomaterials 2022, 290, 121831.

 A 2D Nanoradiosensitizer Enhances Radiotherapy and Delivers STING Agonists to Potentiate Cancer Immunotherapy 

Taokun Luo, Geoffrey T Nash, Xiaomin Jiang, Xuanyu Feng, Jianming Mao, Jianqiao Liu, Aditya Juloori, Alexander T Pearson, Wenbin Lin*
Adv. Mater. 2022, 34, 2110588.

 Tumor‐Activatable Nanoparticles Target Low‐Density Lipoprotein Receptor to Enhance Drug Delivery and Antitumor Efficacy 

Xiaomin Jiang, Wenbo Han, Jianqiao Liu, Jianming Mao, Morten J Lee, Megan Rodriguez, Youyou Li, Taokun Luo, Ziwan Xu, Kaiting Yang, Marc Bissonnette, Ralph R Weichselbaum, Wenbin Lin*
Adv. Sci. 2022, 2201614.

 Nanoscale coordination polymers for combined chemotherapy and photodynamic therapy of metastatic cancer 

Youyou Li, Wenbo Han, Chunbai He, Xiaomin Jiang, Yingjie Fan, Wenbin Lin*
Bioconjugate Chem. 2021, 32, 2318-2326.

 Nanoscale metal–organic framework confines zinc-phthalocyanine photosensitizers for enhanced photodynamic therapy 

Taokun Luo, Geoffrey T Nash, Ziwan Xu, Xiaomin Jiang, Jianqiao Liu, Wenbin Lin*
J. Am. Chem. Soc. 2021, 143, 34, 13519–13524.

 Supramolecular metal-based nanoparticles for drug delivery and cancer therapy 

Xiaomin Jiang, Chunbai He, Wenbin Lin*
Curr. Opin. in Chem. Biol., 2021, 61, 143-153.

 Point-source burst of coordination polymer nanoparticles for tri-modality cancer therapy 

Xiang Ling#, Wenbo Han#, Xiaomin Jiang#, Xing Chen, Megan Rodriguez, Pingping Zhu, Tong Wu, Wenbin Lin*
Biomaterials 2021, 270, 120690.

 Sequential treatment of bioresponsive nanoparticles elicits antiangiogenesis and apoptosis and synergizes with a CD40 agonist for antitumor immunity 

Xiang Ling, Xiaomin Jiang, Youyou Li, Wenbo Han, Megan Rodriguez, Ziwan Xu, Wenbin Lin*
ACS Nano 2021, 15, 765-780.

 Nanoscale metal–organic frameworks stabilize bacteriochlorins for type I and type II photodynamic therapy 

Taokun Luo, Kaiyuan Ni, August Culbert, Guangxu Lan, Zhe Li, Xiaomin Jiang, Michael Kaufmann, Wenbin Lin*
J. Am. Chem. Soc. 2021, 143, 34, 13519–13524.

 The cytochrome c–cyclo [6] aramide complex as a supramolecular catalyst in methanol 

Wang Pan, Lijun Mao, Mingsong Shi, Yonghong Fu, Xiaomin Jiang, Wen Feng, Youzhou He, Dingguo Xu, Lihua Yuan*
New J. Chem., 2018, 42, 3857-3866.